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Metformin Use

Metformin is mainly used for the management of type 2 diabetes mellitus which is also called non insulin dependent diabetes mellitus (NIDDM). Metformin is prescribed when diabetes is not controlled by diet alone. Metformin can be used concomitantly with insulin or sulfonurea in order to achieve desired glucose regulation.
Investigational use of Metformin includes gestational diabetes mellitus (GDM), polycystic ovary syndrome (PCOS) and HIV lipodystrophy syndrome.

Pregnancy And Lactation: Risk factor B is involved with the use of Metformin during pregnancy. Metformin may enter breast milk, therefore it is not recommended for use by lactating mothers.

Contraindications: Metformin is contraindicated in case of hypersensitivity to the active ingredient or any other component of the drug. For renal dysfunction and abnormal creatinine clearance due to any other reason, Metformin use should be avoided. Metformin is contraindicated for patients with acute or chronic metabolic acidosis (with or without coma). The use of Metformin should be discontinued in case of severe conditions such as cardio vascular collapse, acute myocardial infarction, respiratory disorder (or failure), septicemia and acute congestive heart failure. Metformin may increase the risk of lactic acidosis. Since Metformin is eliminated by kidneys, therefore should not be given to the patients with impaired renal function. Metformin should be given with caution to the patients with impaired liver. buy effexor online no prescription

Adverse Reactions Of Metformin: Gastrointestinal disorders include nausea, vomiting and diarrhea. Metformin may have adverse effects over cardiovascular system and may cause palpitations, chest discomfort and flushing. Adverse reactions associated with central nervous system include dizziness, headache, lightheadedness and chills.
Other undesirable effects of Metformin include rash over skin, hypoglycemia, abdominal discomfort, constipation, abnormal bowel movement, myalgia, dyspnea, nail problems, decreased level of vitamin B12, megaloblastic anemia, change in taste, increased thirst, increased sweating, pneumonitis and lactic acidosis.

Dosage: Metformin should be taken as prescribed by your doctor. It is not recommended to start taking this medicine yourself or alteration in the dose. The extended release tablet of Metformin should not be chewed or broken as the effect of Glucophage XR (extended release) may achieve earlier than expected leading towards complication.
Pediatric dosage for children between 10 to 16 years is 500mg twice daily for the management of type 2 diabetes mellitus. After a week interval, dose may be increased by 500mg with a maximum of 2000 mg per day in divided doses. Metformin should not be taken empty stomach.
Adult dose of Metformin for type 2 diabetes mellitus for adults equal to or greater than 17 years, 500mg twice daily or 850mg once a day. Dose increment may be done as follows: buy paxil online no prescription
- 500mg- one tablet per day at weekly intervals
- 850mg - one tablet per day every other week buy sinequan online no prescription
If a dose of greater or equal to 2000mg is required, then for better tolerance, Metformin should be given in 3 divided doses with maximum of 2550mg per day.

Metformin Interactions: Metformin levels may be increased by cimetidine and furosemide. Avoid using Metformin with alcohol as it may cause hypoglycemia. Drugs that may cause hyperglycemia such as diuretics, calcium channel blocker, phenytoin, isoniazid, oral contraceptives etc. may produce impaired glucose regulation.

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